That's as clean as they come. I will say that mechanical inclination is required to keep this thing free of minor issues.
Regular oil changes (5000 with full synthetic at most) will keep the motor free of issues. I have 250,000 miles on mine and no internal work has been done whatsoever.
I'd estimate I've spent around $100 on sparkplugs/sensors etc over the course of 80,000 miles (this is only in reference to the motor). I'm not kidding when I say the straight six will outlast you.
The transmission is where some issues start. It is a 4l60e, so a feather foot is your best friend. This truck has some power. I can say with great confidence that I've redlined my truck several hundreds of times. And I've been through multiple transmissions. The engine doesn't mind the abuse.
Wheel bearings will come up in the future. Use AC Delco or precision wheel bearings. Nothing cheaper unless you want to do it every summer.
Other than that, if you have OCD like me, expect to be nickel and dimed to death on all the little things. These are non power train related issues that will pop up over time. The truck will run and drive like a dream, but there will be minor issues and they can stack up fast.
Loose suspension, emissions/ cat issues, loose plastic, mirrors, steering/ stabilitrack, airbag sensors, loose clips. The list goes on.
Most of these issues come up around the 170-200k mark. If you fix them, the cycle will repeat and the fixes will last another 150k, or the straight six dies. Whichever comes first.
My advice, keep the car clean, and sell around 160k for the best, bang for buck 37k of use.
After that point the truck falls into a lower bracket of resale value and you will lose money if you plan to fix everything that breaks.
The power train will last forever, so driving it until it literally breaks is an option. But I would take the advice from above.